Shelf life (days): 1460.0
Formulation: A solid
Formal Name: L-threonyl-L-a-glutamyl-L-alanyl-L-threonyl-L-isoleucyl-L-threonylglycyl-L-leucyl-L-a-glutamyl-L-prolylglycyl-L-threonyl-L-a-glutamyl-L-tyrosyl-L-threonyl-L-isoleucyl-L-tyrosyl-L-valyl-L-isoleucyl-L-alanyl-L-leucine, sodium salt
Amino Acids: TEATITGLEPGTWYTIYVIAL-OH
Purity: ≥95%
Formula Markup: C103H163N21O35 / XNa
Formula Weight: 2255.5
Notes: FNIII14 is an inhibitor of cell adhesion and a peptide derived from the 14th type III repeat, which is part of heparin-binding domain 2, of human, mouse, and rat fibronectin.{69935,69936} It inhibits the adhesion of A375-SM melanoma cells to fibronectin-coated plates when used at a concentration of 200 µg/ml.{69935} FNIII14 (100 µg/ml) inhibits the binding of an antibody targeting the active conformation of the fibronectin receptor β1 integrin on K562 cells, which endogenously express integrin α5β1 as its only β1 integrin, and induces the differentiation of ST 13 fibroblasts into adipocytes.{69936} It decreases atherosclerotic plaque formation in Ldlr-/- mice fed a Western diet.{69937} FNIII14, in combination with the antitumor antibiotic doxorubicin (Item No. 15007), reduces metastatic tumor burden in a 4T1 murine mammary model of metastasis.{69938}
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