Product Description: Forphenicinol is an immunomodulator and a derivative of the bacterial metabolite forphenicine. It increases the phagocytosis of yeast by peritoneal macrophages isolated from thioglycolate-stimulated mice. Forphenicinol (100 μg/animal) prevents cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH), as well as enhances DTH in response to the hapten oxazolone or sheep red blood cells in mice. It enhances the bactericidal activity of macrophages against P. aeruginosa in mice when administered at a dose of 0.5 mg/kg.2 Forphenicinol (15.6-1,000 μg/animal) increases survival in a mouse model of P. aeruginosa infection. It also inhibits tumor growth in S180 sarcoma and IMC carcinoma mouse xenograft models when administered at doses ranging from 0.05 to 5 mg/kg per day.
Applications: COVID-19-immunoregulation
Formula: C9H11NO4
References: [1]Ishizuka, et al. Studies on effects of forphenicinol on immune responses. J. Antibiot. (Tokyo) 35(8), 1042-1048 (1982).
CAS Number: 71522-58-2
Molecular Weight: 197.19
Research Area: Infection
Target: Bacterial
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