Shelf life (days): 1460.0
Formulation: A solid
Formal Name: L-tyrosyl-L-valyl-L-methionylglycyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-L-a-aspartyl-L-arginyl-L-phenylalaninamide, trifluoroacetate salt
Amino Acids: YVMGHFRWDRF-NH2
Purity: ≥95%
Formula Markup: C72H97N21O14S / XCF3COOH
Formula Weight: 1512.7
Notes: γ1-Melanocyte-stimulating hormone (γ1-MSH) is a peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland.{69889} It selectively binds to melanocortin receptor 1 (MC1R) and MC3R over MC4R and MC5R (Kis = 0.025, 0.063, >100, and >100 µM, respectively, in insect cells expressing the human receptors) but also binds to opioid receptors in rat brain tissue homogenates (IC50 = 5.9 µM).{69890,69891} γ1-MSH (10 µM) inhibits contractions induced by the neuropeptide FMRF-amide in isolated M. edulis catch muscle.{69892} Intracisternal administration of γ1-MSH (0.3 nmol/animal) increases the latency to tail flick in the tail-flick test and inhibits haloperidol-induced catalepsy in mice.{69893} γ1-MSH (0.01 nmol/animal) also inhibits LPS-induced nitric oxide (NO) release in mouse forebrain in vivo.{69890}
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