Shelf life (days): 365.0
Formulation: Lyophilized from sterile PBS, pH 7.4
Uniprot ID: P48546
Purity: ≥95% as determined by SDS-PAGE
Formula Weight: 0.0
Notes: Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane glycoprotein hormone receptor and class B1 G protein-coupled receptor (GPCR).{67910} It is composed of an N-terminal extracellular domain required for ligand binding, seven transmembrane domains, and a C-terminal intracellular domain. GIPR is expressed in adipose tissue and the pancreas, gut, heart, pituitary gland, adrenal cortex, and brain and localizes to the plasma membrane.{67911,67912} It is involved in insulin and glucagon secretion, bone remodeling, and lipid metabolism, is activated by the endogenous ligands GIP (1-42) and GIP (1-30) amide, and induces primarily Gαs signaling.{67913,67911,67914} Knockout of GIPR increases lipolysis in white adipose tissue and reduces body weight gain and fat mass in a mouse model of obesity induced by a high-fat diet.{67913} SNPs in GIPR are associated with type 2 diabetes.{67915} Cayman’s GIPR Extracellular Domain (human, recombinant; aa 26-138) protein can be used for binding assays. This protein consists of 124 amino acids, has a calculated molecular weight of 14.42 kDa, and a predicted N-terminus of Gly26 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 25.7 kDa due to glycosylation.
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