Shelf life (days): 1460.0
Formulation: A solid
Formal Name: L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysylglycyl-L-argininamide, trifluoroacetate salt
Amino Acids: FIAWLVKGR-NH2
Purity: ≥98%
Formula Markup: C54H85N15O9 / XCF3COOH
Formula Weight: 1088.4
Notes: Glucagon-like peptide 1 (GLP-1) (28-36) amide is a peptide and an active metabolite of the endogenous GLP-1R agonist GLP-1 (7-36) amide (Item No. 15069).{67831,67832} It is formed from GLP-1 (7-36) amide by neprilysin (NEP).{67832} GLP-1 (28-36) amide (100 nM) inhibits decreases in ATP levels induced by hydrogen peroxide and increases in reactive oxygen species (ROS) levels induced by tert-butyl hydroperoxide (t-BHP) in primary mouse hepatocytes and H-4-II-E hepatoma cells.{67831} It reduces body weight gain, the ratio of weight gain to food intake, and hepatic gluconeogenesis in a mouse model of obesity induced by a high-fat diet (HFD) when administered at a dose of 18.5 nmol/kg per day.{67833} GLP-1 (28-36) amide decreases plasma levels of glucose and insulin and hepatic triglyceride levels in a mouse model of obesity induced by a very high-fat diet (VHFD) when infused at a rate of 18.5 nmol/kg per day.{67834}
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