GPX4-IN-6, CAS 2922824-07-3

Shelf life (days): 1460

Info: A covalent GPX4 inhibitor (IC50 = 130 nM); inhibits the growth of MDA-MB-468, BT-549, and MDA-MB-231 cells (IC50s = 12, 3.4, and 8 nM, respectively); increases lipid peroxidation and MDA levels in MDA-MB-231 cells at 10 and 20 µM; decreases mitochondrial volume and induces degradation of mitochondrial crests and outer membranes in MDA-MB-231 cells at 20 µM; reduces tumor volume and weight, without affecting body weight, in an MDA-MB-231 mouse xenograft model at 10 or 20 mg/kg per day

Formulation: A solid

Formal Name: 2-bromo-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)-acetamide

Purity: ≥98%

Formula Markup: C18H17BrFNO5

Formula Weight: 426.238403

CAS Number: 2922824-07-3

• SKU: CAY43037-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 43037-50
• Package Unit: 50 mg
• Quantity Unit: STK