Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/2403), CF740 conjugate, 0.1mg/mL

Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/2403), CF740 conjugate, 0.1mg/mL
SKU
BTMBNC742403-500
Packaging Unit
500 uL
Manufacturer
Biotium

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Description: Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)

Conjugate: CF740

Concentration: 0.1 mg/mL

Storage buffer: PBS, 0.1% rBSA, 0.05% azide

Clone: GZMB/2403

Immunogen: Recombinant fragment of human GZMB protein (around aa 73-187) (exact sequence is proprietary)

Antibody Reactivity: Granzyme B

Entrez Gene ID: 3002

Antibody Application Notes: For coating for ELISA, order Ab without BSA/Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Optimal dilution and staining procedure for a specific application should be determined by user/Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry
More Information
SKU BTMBNC742403-500
Manufacturer Biotium
Manufacturer SKU BNC742403-500
Package Unit 500 uL
Quantity Unit STK
Reactivity Human
Clonality Monoclonal
Isotype IgG2b
Host Mouse
Conjugate Conjugated, CF740
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