Clone: P3G9A8.
Background: The antibody to HBsAG is used for the detection of this antigen in liver cells, which are infected by hepatitis B virus. In healthy liver and other tissues staining is negative. Hepatitis B Virus is a widely distributed Virus, which is known as the main cause of liver cirrhosis. A long-term consequence of hepatitis B infection could be the development of liver carcinoma. Especially medical personal is affected by hepatitis B (due to inappropriate handling of virus contaminated material!) HBsAg subtypes ad and ay.
Positive Control: HBV-infected liver.
Immunogen: Purified Hepatitis B surface antigen.
Purification Method: Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**. The volume is sufficient for at least 100 immunohistochemical tests (100 µl working solution / test). Use appropriate antibody diluent e.g. BIOLOGO Art .No. PU002.
References: 1. Beasley R.P., et al. (1981) Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22,707 men in Taiwan. Lancet ii; 1129 2. Hoofnagel J.H., and Alter H.J. (1984) Chronic viral hepatitis. In: Vyas G.N. et al. Eds. Viral hepatitis and liver disease. Grune & Stratton, N.Y. pp 97 ff. 3. Swensen P.D. et al. (1988). Antigenic analysis of HBsAg with monoclonal antibodies specific for S protein and pre-S2. Viral hepatitis and liver disease. Alan R. Liess, Inc. pp. 627ff.
Caution: *These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals. ** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!
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