CRISPR

CRISPR

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) are segments of short, regularly placed palindromic nucleotide repetitions. CAS (CRISPR-Associated Protein) is a CRISPR-associated nuclease enabling controlled DNA cleavage.

CRISPR/Cas9 systems allow for targeted gene editing. Briefly, aCRISPR/Cas9 complex binds to a specific DNA sequence, cuts it out and replaces the original sequence with a new sequence. Guide RNA (gRNA) helps to navigate the CRISPR/Cas9 complex in order to target only the specific sequence.

CRISPR/Cas9 represents a valuable tool in gene editing and becomes even more popular in therapy, especially of cancer and other disease involving genetic defects (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315587/).

Picture: CRISPR/Cas9 induced DNA double-strand break.

Highlights:

  • Double nickase plasmids
  • CRISPR/dCas9 activation plasmids
  • CRISPR/dCas9 lentiviral activation particles
  • CRISPR/Cas9 plasmids
  • HDR plasmids
  • CRE vector
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  1. BCMA CRISPR/Cas9 Lentivirus (Non-Integrating)
    BCMA CRISPR/Cas9 Lentivirus (Non-Integrating)
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    Sku BPS78894
    Manufact. Sku78894
    Packaging Unit500 µl x 2
  2. BCMA CRISPR/Cas9 Lentivirus (Integrating)
    BCMA CRISPR/Cas9 Lentivirus (Integrating)
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    Sku BPS78893
    Manufact. Sku78893
    Packaging Unit500 µl x 2
  3. Cas9 Lentivirus (Inducible Tet-On)
    Cas9 Lentivirus (Inducible Tet-On)
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    Sku BPS78794
    Manufact. Sku78794
    Packaging Unit500 µl x 2
  4. NLRP3 CRISPR/Cas9 Lentivirus (Non-Integrating)
    NLRP3 CRISPR/Cas9 Lentivirus (Non-Integrating)
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    Sku BPS78546
    Manufact. Sku78546
    Packaging Unit500 µl x 2
  5. NLRP3 CRISPR/Cas9 Lentivirus (Integrating)
    NLRP3 CRISPR/Cas9 Lentivirus (Integrating)
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    Sku BPS78545
    Manufact. Sku78545
    Packaging Unit500 µl x 2
  6. FCGR2A CRISPR/Cas9 Lentivirus (Non-Integrating)
    FCGR2A CRISPR/Cas9 Lentivirus (Non-Integrating)
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    Sku BPS78538
    Manufact. Sku78538
    Packaging Unit500 µl x 2
  7. FCGR2A CRISPR/Cas9 Lentivirus (Integrating)
    FCGR2A CRISPR/Cas9 Lentivirus (Integrating)
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    Sku BPS78537
    Manufact. Sku78537
    Packaging Unit500 µl x 2
  8. TGFBR2 CRISPR/Cas9 Lentivirus (Non-Integrating)
    TGFBR2 CRISPR/Cas9 Lentivirus (Non-Integrating)
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    Sku BPS78536
    Manufact. Sku78536
    Packaging Unit500 µl x 2
  9. TGFBR2 CRISPR/Cas9 Lentivirus (Integrating)
    TGFBR2 CRISPR/Cas9 Lentivirus (Integrating)
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    Sku BPS78535
    Manufact. Sku78535
    Packaging Unit500 µl x 2
  10. CRBN CRISPR/Cas9 Lentivirus (Non-Integrating)
    CRBN CRISPR/Cas9 Lentivirus (Non-Integrating)
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    Sku BPS78518
    Manufact. Sku78518
    Packaging Unit500 µl x 2
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