Target: HCN1
Conjugate: HRP
Product Type: Monoclonal
Clone Number: S70
Immunogen: Fusion protein amino acids 778-910 (C terminus) of rat HCN1
Swiss-Prot: Q9JKB0
Purification: Protein G Purified
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Concentration: 1 mg/ml
Specificity: Detects ~100kDa. No cross-reactivity against HCN2.
Cellular Localization: Membrane
Scientific Background: Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, play a crucial role in the regulatons of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in both the heart and brain (1).
References: 1. Zong X., et al. (2005) J Biol Chem. 280(40): 34224-34232.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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