HM03, CAS 500565-15-1

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-phenol

Purity: ≥98%

Formula Markup: C26H27ClN4O2

Formula Weight: 463.0

CAS Number: 500565-15-1

Notes: HM03 is an inhibitor of the protein-protein interaction between the DNA excision repair protein ERCC-1 and the DNA repair endonuclease XPF (IC50 = 1.86 µM).{67826} It is also an inhibitor of D-alanine-D-alanine ligase B (DdlB; Ki = 218 µM for the E. coli enzyme).{67827} HM03 is active against E. coli and S. aureus (MICs = 64 and 32 µg/ml, respectively). It potentiates cytotoxicity induced by cisplatin (Item No. 13119) in A549 lung and HCT116 colon cancer cells when used at a concentration of 100 µM.{67828}

• SKU: CAY40908-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40908-50
• Package Unit: 50 mg
• Quantity Unit: STK