Clone: C1P5.
Background: This antibody is used for the detection of high risk Human Papilloma virus (HPV) infections in different tissues. It should always be used when the screening antibody has detected the presence of papillomavirus in suspected tissues. Human Papilloma virus type 16 and 18 are responsible for the development of cervical carcinoma, as well as carcinomas of the head and neck region and some other tumors.
Positive Control: HPV-positive vulva carcinoma.
Immunogen: HPV type 18 E6 protein produced in bacteria.
Purification Method: Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**. The volume is sufficient for at least 30 immunohistochemical tests (100 µl working solution / test). Use appropriate antibody diluent e.g. BIOLOGO Art. No. PU002 if required.
Source: Mouse immunized with recombinant E6 protein fro HPV18.
Specificity: Human Papillomavirus Early Antigen E6 from HPV 16 and 18.
References: 1. Cowsert et al. (1987) J. Natl. Cancer Inst. 79; 1053-1057. 2. Banks L.J. (1987) J. Gen. Virol. 68; 1351-1355. 3. Cason J., Patel D., Naylor J., et al. (1989) Identification of immunogenic regions of the major coat protein of human papillomavirus type 16 that contain type-restricted epitopes. J. General Virol. 70; 2973-2987. 4. Shepherd P.S., Lunny D., Brooks R., et al. (1992) The detection of human papilloma viruses in cervical biopsies by immunohistochemistry and in situ hybridization. Scand. J. Immunol. 36(11); 69-74.
UniProt: P06463.
Caution: *These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals. ** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!
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