Product Description: HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].
Applications: Cancer-programmed cell death
Formula: C13H12O4S
References: [1]Hwang SY, et al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shockprotein 27. Eur J Med Chem. 2017 Oct 20;139:892-900./[2]Younghwa Na, et al. Methods for treating pulmonary fibrosis using chromenone derivatives.
CAS Number: 2133499-85-9
Molecular Weight: 264.30
Compound Purity: 99.70
Research Area: Cancer
Solubility: DMSO : 20 mg/mL (ultrasonic)
Target: HSP
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