Background: IFN-gamma is a soluble cytokine that is a member of the type II interferon class. It is produced by immune cells such as T-cells and NK cells and plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. [taken from NCBI Entrez Gene (Gene ID: 3458)].