Product Description: Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC50s in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active[1][2][3][4][5].
Applications: Cancer-programmed cell death
Formula: C30H50O2
References: [1]Nakata T, et al. Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem. 2007;15(1):257-264./[2]Zhang SD, et al., Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells. Phytomedicine. 2019 Jul;60:152957./[3]Li Y, et al. Inotodiol protects PC12 cells against injury induced by oxygen and glucose deprivation/restoration through inhibiting oxidative stress and apoptosis[J]. Journal of Applied Biomedicine, 2018, 16(2): 126-132./[4]Lee SH, et al., Antiaging effect of inotodiol on oxidative stress in human dermal fibroblasts. Biomed Pharmacother. 2022 Sep;153:113311./[5]Liu Y, et al., Inotodiol, an antiasthmatic agent with efficacy and safety, preferentially impairs membrane-proximal signaling for mast cell activation. Int Immunopharmacol. 2023 Apr;117:109854.
CAS Number: 35963-37-2
Molecular Weight: 442.72
Compound Purity: 98.29
Research Area: Cancer; Inflammation/Immunology; Neurological Disease
Solubility: 10 mM in DMSO
Target: Apoptosis;Caspase;MDM-2/p53;MMP;NF-κB;p38 MAPK;SOD;Toll-like Receptor (TLR)
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