Product Description: Iperoxo is a potent superagonist of muscarinic acetylcholine receptor (mAChR) that activates M1, M2 and M3 receptors with pEC50 of 9.87, 10.1 and 9.78. Iperoxo can be used for direct probing activation-related conformational transitions of muscarinic receptors when labeled with tritium[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C10H17IN2O2
References: [1]Schrage R, et, al. Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor. Br J Pharmacol. 2013 May;169(2):357-70./[2]Schrage R, et, al. New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo. Biochem Pharmacol. 2014 Aug 1;90(3):307-19./[3]Kruse AC, et al., Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 2013 Dec 5;504(7478):101-6./[4]Matera C, et al., Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity. Eur J Med Chem. 2014 Mar 21;75:222-32.
CAS Number: 247079-84-1
Molecular Weight: 324.16
Compound Purity: 99.48
Research Area: Neurological Disease
Solubility: DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: mAChR
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