Clone Name: MSVA-880M
Light Chain: Kappa
Product Description: This antibody was validated on 76 different Normal Tissues by IHC-P.
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Application Note: IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 83
Positive Control: Tonsil: A strong staining should be seen in the nuclei of all cells.
Negative Control: A tumor or a cell line with documented loss of Ku80 expression.
Form: Liquid
Buffer (with preservative): PBS, 0.05% BSA (Please contact us for PBS only format), 0.05% sodium azide.
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
Uniprot ID: P13010
Antigen Species: Human
Immunogen: Recombinant human XRCC5 fragmen
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: X-ray repair cross complementing 5
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