Clone Name: 11A2
Application Note: WB: 1:500 - 1:1000. FCM: 1:10 - 1:20. ELISA: 1:100 - 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 95
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: 200 μg/ml (Please refer to the vial label for the specific concentration.)
Background: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Uniprot ID: P01130
Antigen Species: Human
Immunogen: Recombinant Human LDL R
Purification: Protein G purified
Conjugation: Unconjugated
Full Name: low density lipoprotein receptor
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