Loncastuximab Tesirine, CAS 1879918-31-6

Loncastuximab Tesirine, CAS 1879918-31-6
SKU
BPS82918-2
Packaging Unit
500 µg
Manufacturer
BPS Bioscience

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Background: B-lymphocyte antigen CD19 (Cluster of Differentiation 19), also known as B-Lymphocyte Surface Antigen B4 and CVID3C, is a transmembrane protein expressed in follicular dendritic cells and all B lineage cells except plasma cells. CD19 plays two major roles in human B cells. It acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane and it works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Due to its presence on all B cells, it is a biomarker for B lymphocyte development and lymphoma diagnosis and can be utilized as a target for leukemia immunotherapies. CD19-targeted therapies based on T cells that express CD19-specific chimeric antigen receptors (CARs) have been utilized for their antitumor abilities in patients with CD19+ lymphoma and leukemia, such as Non-Hodgkins Lymphoma (NHL), CLL and ALL.

CAS Number: 1879918-31-6

Description: Loncastuximab tesirine is a human cluster of differentiation 19 (CD19)-directed antibody-drug conjugate (ADC). Once bound to CD19 on the cell membrane, loncastuximab tesirine is rapidly internalised and triggers cell death. Loncastuximab tesirin induces cell apoptosis, it can be used for the research of diffuse large B-cell lymphoma1,2.

Format: Aqueous buffer solution.

Purity: ≥90%

Storage Stability: Store at -80°C, protect from light

Target: CD19

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Sachini, et al., 2021 Blood 138(1):2273.2. Zammarchi F, et al., 2018 Blood 131(10):1094-1105.
More Information
SKU BPS82918-2
Manufacturer BPS Bioscience
Manufacturer SKU 82918-2
Package Unit 500 µg
Quantity Unit STK
Clonality Monoclonal
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