Target: LRP4
Conjugate: FITC
Product Type: Monoclonal
Clone Number: N207/27 (Formerly sold as S207-27)
Immunogen: Fusion protein amino acids 26- 350 (extracellular N-terminus) of mouse LTP4
Swiss-Prot: Q8VI56
Purification: Protein G Purified
Storage Buffer: 640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS
Concentration: 1 mg/ml
Specificity: Detects the extracellular domain of LRP4 ~215kDa. Degradation product can be seen at ~150kDa.
Cellular Localization: Membrane
Scientific Background: Potential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes. It is involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway.
References: 1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353–92.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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