Target: LRP4
Conjugate: HRP
Product Type: Monoclonal
Clone Number: N207/27 (Formerly sold as S207-27)
Immunogen: Fusion protein amino acids 26- 350 (extracellular N-terminus) of mouse LTP4
Swiss-Prot: Q8VI56
Purification: Protein G Purified
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Concentration: 1 mg/ml
Specificity: Detects the extracellular domain of LRP4 ~215kDa. Degradation product can be seen at ~150kDa.
Cellular Localization: Membrane
Scientific Background: Potential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes. It is involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway.
References: 1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353–92.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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