Mal-N(Me)-C6-N(Me)-PNU-159682, CAS 2682939-57-5

Product Description: Mal-N(Me)-C6-N(Me)-PNU-159682 (Compound 27), an agent-linker conjugate for ADC, consists the ADC linker Mal-N(Me)-C6-N(Me) and a potent ADC cytotoxin PNU-159682. Mal-N(Me)-C6-N(Me)-PNU-159682 (Compound 27) selectively delivers the payload to CD46-expressing cells, where the linker is cleaved by cathepsin B to release PNU-159682, inducing DNA damage and apoptosis. Mal-N(Me)-C6-N(Me)-PNU-159682 shows durable tumor regression in xenograft (PDX) models of non-small cell lung cancer (NSCLC) and colorectal cancer (CRC)[1].

Formula: C47H56N4O17

References: [1]Holte D, et al. Evaluation of PNU-159682 antibody drug conjugates (ADCs). Bioorg Med Chem Lett. 2020 Dec 15;30(24):127640.

CAS Number: 2682939-57-5

Molecular Weight: 948.96

Research Area: Cancer

Target: Apoptosis;Drug-Linker Conjugates for ADC

• SKU: MEXHY-171509-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-171509-0
• Package Unit: Get quote
• Quantity Unit: STK