Notes: Melanostatin is an endogenous peptide.{51903,24276} It is formed from pro-neuropeptide Y when pro-neuropeptide Y is cleaved into melanostatin and C-flanking peptide of neuropeptide Y (NPY).{24276} Melanostatin inhibits α-melanocyte-stimulating hormone (α-MSH) release from primary frog neurointermediate lobes (NILs; ED50 = 100 nM).{51903} It inhibits thyrotropin-releasing hormone-induced increases in intracellular calcium in primary frog melanotrope cells when used at a concentration of 100 nM. Intracerebroventricular administration of melanostatin (5 or 10 nmol/kg) increases food intake in frog larvae.{51904} It increases mean blood pressure in normotensive sharks when administered at a dose of 5 nmol/kg.{51905}