Shelf life (days): 1460.0
Formulation: A solid
Formal Name: L-a-aspartyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-L-argininamide, acetate
Amino Acids: DYwVwwR-NH2
Purity: ≥98%
Formula Markup: C57H68N14O10 / XC2H4O2
Formula Weight: 1109.259
Notes: An NK2 receptor antagonist; inhibits NKA-induced contractions in endothelium-deprived isolated rabbit pulmonary artery (pA2 = 7.89), which is endogenously enriched in NK2 receptors; selective for NK2 receptors in isolated rabbit pulmonary artery over NK2 receptors in isolated hamster trachea (pA2 = 5.9 using NKA as an agonist) and NK1 receptors in isolated guinea pig ileum (pA2 = 5.52 using substance P methyl ester as an agonist), tissues that highly express these respective receptors, as well as NK3 receptors in isolated guinea pig cerebral cortex membranes (Ki = >10 μM); inhibits [β-Ala8]-NKA (4-10)-induced increases in bladder motility in anesthetized rats, as well as [β-Ala8]-NKA (4-10)-induced increases in bronchoconstriction in anesthetized guinea pigs at 1 μmol/kg; induces bladder motility in anesthetized rats and bronchoconstriction in guinea pigs when administered alone
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