Application Note: WB: 1:500-1:3000. ICC/IF: 1:100-1:500. IHC-P: 1:50-1:200l. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 55
Form: Liquid
Buffer (with preservative): PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium Azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
Uniprot ID: P24347
Antigen Species: Human
Immunogen: A synthesized peptide derived from human MMP11, corresponding to a region within N-terminal amino acids.
Purification: Purified by antigen-affinity chromatography
Conjugation: Unconjugated
Full Name: matrix metallopeptidase 11
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