Clone Number: EBS-O-110
Immunogen: human PBL and HLA-homozygous B-LCL line
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.
Applications: FC, IHC-fr, IF
References: Sparrow RL, et al., Transplantation 42: 647-652 (1986)/Chorvath B et al. Neoplasma 34(4): 417-425 (1987)/Horejsi V et al. Tissue Antigens 32(1): 6-11 (1988)
English
Deutsch
