Clone Number: L10CC10
Immunogen: Pepsinogen II purified from human tissue
Concentration: 100 ug/ ml
Storage buffer: PBS with 1% BSA & 0.09% sodium azide
Additional info: The antibody is specific to human pepsinogen II and has no crossreactivity to human pepsinogen I. Pepsinogen II is a group of precursor molecules for pepsin. These proteins are secreted into the gastric lumen by the pyloric glands of the gastric antrum and also by the chief and neck cells of the gastric corpus (oxyntic mucosa). Negative immunohistochemical reaction for pepsinogen I (right) but positive reaction for pepsinogen II (left) is a typical sign of the antral mucosa and, in the presence of atrophic gastritis, this staining pattern indicates that the positive glands and cells are metaplastic and “pyloric” in differentiation (so called pseudopyloric metaplasia).
Applications: IHC-fr, IHC-P, WB, ELISA
English
Deutsch
