MR22, CAS 3027761-24-3

Shelf life (days): 1460

Info: A SIK inhibitor (IC50s = 72, 89, and 18 nM for SIK1, SIK2, and SIK3, respectively); selective for SIK1-SIK3 over EPHA1-EPHA4 (IC50s = 0.145-2.1 µM), EPHB1-EPHB4 (IC50s = 0.607-22.6 µM), Abl1 (IC50 = 28.1 µM), JNK1 (IC50 = 23.2 µM), GAK (IC50 = 33.8 µM), and RSK1B (IC50 = >45 µM); induces cell cycle arrest at the G1 phase and reduces rapamycin-induced Akt phosphorylation in SKOV3 ovarian cancer cells at 5 µM

Formulation: A solid

Formal Name: 8-(4-aminobutyl)-6-(2,5-difluorophenyl)-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one

Purity: ≥98%

Formula Markup: C18H19F2N5O

Formula Weight: 359.380806

CAS Number: 3027761-24-3

• SKU: CAY9004611-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 9004611-25
• Package Unit: 25 mg
• Quantity Unit: STK