Description: This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.
Product origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: 1-13M1
Immunogen: M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient
Antibody Reactivity: MUC5AC
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- Am J Respir Crit Care Med (2001) 163: 517-523. (IHC, FFPE)
- Oncotarget (2015) 6(6): 4274-4285. (WB)
- Int J Cancer (1998) 75:767-773. (RIA)
- Exp Eye Res (2007) 84(5): 939-950. (WB)
- Am J Gastroenterol (2017) 112(1): 172-183. (ELISA)
Entrez Gene ID: 4586
Expected AB Applications: RIA (published for clone)/IHC (FFPE) (published for clone)/WB (published for clone)
Z-Antibody Applications: IHC, FFPE (published)/RIA (published)/WB (published)
Antibody Application Notes: Does not react with Pig or Hedgehog/ELISA: For coating, purchase antibody without BSA/Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Optimal dilution for a specific application should be determined by user
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