Shelf life (days): 1460.0
Formulation: A solid
Formal Name: L-a-glutamyl-L-isoleucylglycyl-L-a-aspartyl-L-a-glutamyl-L-a-glutamyl-L-asparaginyl-L-seryl-L-alanyl-L-lysyl-L-phenylalanyl-L-prolyl-L-isoleucinamide, trifluoroacetate salt
Amino Acids: EIGDEENSAKFPI-NH2
Purity: ≥95%
Formula Markup: C63H98N16O23 / XCF3COOH
Formula Weight: 1447.6
Notes: Neuropeptide EI (NEI) is an endogenous peptide fragment of rat prepro-melanin concentrating hormone (MCH) that is involved in hormone release, grooming behavior, and motor activity.{49913} NEI corresponds to amino acids 140-152 of rat prepro-MCH and 131-143 of human, mouse, and rat prepro-MCH. It is expressed in both the central and peripheral nervous systems, localizes to the cytoplasm, and colocalizes with MCH in the CNS.{49913,49914} NEI (1 µM) reduces thyrotropin-releasing hormone (TRH) release in mediobasal hypothalamus explants.{49915} Intracerebroventricular administration of NEI increases serum levels of luteinizing hormone (LH) in male rats and in chronically ovariectomized female rats that received estradiol benzoate and progesterone in addition to NEI.{49916} NEI (1 µg/animal, i.c.v.) induces excessive grooming behavior and increases locomotor activity in rats, effects that can be blocked by MCH (Item No. 24462) or α-melanocyte-stimulating hormone (α-MSH; Item No. 29923).{49917} It also increases the amount of time spent in REM sleep in rats when injected intracerebroventricularly or into the ventrolateral periaqueductal grey (vlPAG).
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