NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker) (rNX2/1523), CF740 conjugate, 0.1mg/mL

NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker) (rNX2/1523), CF740 conjugate, 0.1mg/mL
SKU
BTMBNC742309-100
Packaging Unit
100 uL
Manufacturer
Biotium

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Description: Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)

Conjugate: CF740

Concentration: 0.1 mg/mL

Storage buffer: PBS, 0.1% rBSA, 0.05% azide

Clone: rNX2/1523

Immunogen: Human recombinant NKX2.2 protein fragment (around aa1-119) (exact sequence is proprietary)

Antibody Reactivity: NKX2.2

Entrez Gene ID: 4821

Z-Antibody Applications: IHC, FFPE (verified)

Verified AB Applications: IHC (FFPE) (verified)

Antibody Application Notes: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Immunohistology (formalin): 0.5-1 ug/mL for 30 minutes at RT/Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes/Optimal dilution for a specific application should be determined by user
More Information
SKU BTMBNC742309-100
Manufacturer Biotium
Manufacturer SKU BNC742309-100
Package Unit 100 uL
Quantity Unit STK
Reactivity Human
Clonality Recombinant
Application Immunohistochemistry
Isotype IgG1
Host Mouse
Conjugate Conjugated, CF740
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