NR4A3 Ligand-binding Domain (human, recombinant)

Shelf life (days): 365.0

Formulation: 50 mM Tris HCl, pH 7.5, with 100 mM sodium chloride, and 2% glycerol

Uniprot ID: Q92570

Purity: ≥80%

Formula Weight: 0.0

Notes: Nuclear receptor subfamily 4 group A member 3 (NR4A3) is a transcription factor and member of the NR4A orphan nuclear receptor family.{69926,69927} It is composed of an N-terminal activation function-1 (AF-1) transactivation domain, a DNA-binding domain, a variable linker region, and a C-terminal domain comprising a ligand-binding domain and an AF-2 domain. NR4A3 is primarily expressed in the fetal brain and lungs and adult heart and skeletal muscle, with both splice variants showing similar expression patterns.{69928,69929} It is involved in several biological processes, including apoptosis, differentiation, metabolism, inflammation, cardiac remodeling, and development, and its expression can be induced by several factors such as growth factors, cytokines, and stress.{69926,69927} Knockout of Nr4a3 inhibits GM-CSF- and IL-4-induced differentiation of primary mouse monocytes into dendritic cells.{69930} Overexpression of NR4A3 reduces infarct size as a percentage of the area at risk in a mouse model of acute myocardial infarction.{69931} Fusion proteins of NR4A3 with Ewing sarcoma protein (EWS) or TAF15 are associated with extraskeletal myxoid chondrosarcoma.{69932}

• SKU: CAY40344-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40344-100
• Package Unit: 100 µg
• Quantity Unit: STK