Occludin (Marker of Early Blood Brain Barrier Damage)(OCLN/2181), CF740 conjugate, 0.1mg/mL

Occludin (Marker of Early Blood Brain Barrier Damage)(OCLN/2181), CF740 conjugate, 0.1mg/mL
SKU
BTMBNC742181-500
Packaging Unit
500 uL
Manufacturer
Biotium

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Description: Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Occludin is a tight junction protein that is a key structural component of the blood-brain barrier (BBB). Degradation of Occludin is frequently seen in ischemic stroke and contributes to BBB disruption. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)

Conjugate: CF740

Concentration: 0.1 mg/mL

Storage buffer: PBS, 0.1% rBSA, 0.05% azide

Clone: OCLN/2181

Immunogen: Recombinant fragment of human Occludin protein (around aa 282-415) (exact sequence is proprietary)

Antibody Reactivity: Occludin

Entrez Gene ID: 100506658

Z-Antibody Applications: IHC, FFPE (verified)/WB (verified)

Verified AB Applications: IHC (FFPE) (verified)/WB (verified)
More Information
SKU BTMBNC742181-500
Manufacturer Biotium
Manufacturer SKU BNC742181-500
Package Unit 500 uL
Quantity Unit STK
Reactivity Human
Clonality Monoclonal
Application Western Blotting, Immunohistochemistry
Isotype IgG1 kappa
Host Mouse
Conjugate Conjugated, CF740
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