Shelf life (days): 1460.0
Formulation: A neat oil
Formal Name: (3S,4E)-4-formyl-3-(2-oxoethyl)-4-hexenoic acid, 2-(4-hydroxyphenyl)ethyl ester
Purity: ≥95%
Formula Markup: C17H20O5
Formula Weight: 304.3
CAS Number: 289030-99-5
Notes: Oleocanthal is a secoiridoid polyphenol that has been found in O. europaea and has diverse biological activities.{68819,68820,68821,68822} It inhibits the proliferation of CWR-R1ca, PC3, PC-3M, and DU145 prostate cancer cells (IC50s = 3.59, 0.64, 1.03, and 5.35 µM, respectively).{68819} Oleocanthal inhibits the growth of L. major promastigotes and amastigotes in vitro (IC50s = 18.7 and 87 µg/ml, respectively) and reduces lymph node parasite burden in a mouse model of leishmaniasis when administered at a dose of 5 mg/kg.{68820} Oleocanthal (5 mg/kg) reduces hippocampal amyloid-β (Aβ) levels in a TgSwDI transgenic mouse model of Alzheimer’s disease.{68821} Intragastric administration of oleocanthal (5 mg/kg) decreases serum IL-6 and TNF-α levels and reduces lung cell apoptosis in a chicken model of LPS-induced acute lung injury.{68822}
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