p21WAF1 (Tumor Suppressor Protein)(AC8), CF740 conjugate, 0.1mg/mL

p21WAF1 (Tumor Suppressor Protein)(AC8), CF740 conjugate, 0.1mg/mL
SKU
BTMBNC742378-100
Packaging Unit
100 uL
Manufacturer
Biotium

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Description: This MAb recognizes a 21 kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk's and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma). Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)

Conjugate: CF740

Concentration: 0.1 mg/mL

Storage buffer: PBS, 0.1% rBSA, 0.05% azide

Clone: AC8

Immunogen: Recombinant full-length human CDKN1A protein

Antibody Reactivity: p21WAF1

Entrez Gene ID: 1026

Antibody Application Notes: For coating for ELISA, order Ab without BSA/Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Optimal dilution and staining procedure for a specific application should be determined by user/Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry
More Information
SKU BTMBNC742378-100
Manufacturer Biotium
Manufacturer SKU BNC742378-100
Package Unit 100 uL
Quantity Unit STK
Reactivity Human
Clonality Monoclonal
Isotype IgG1 kappa
Host Mouse
Conjugate Conjugated, CF740
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