PD-L2 / PDCD1LG2 / CD273(PDL2/2676), CF740 conjugate, 0.1mg/mL

PD-L2 / PDCD1LG2 / CD273(PDL2/2676), CF740 conjugate, 0.1mg/mL
SKU
BTMBNC742676-500
Packaging Unit
500 uL
Manufacturer
Biotium

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Description: Recognizes a protein of about 31 kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)

Conjugate: CF740

Concentration: 0.1 mg/mL

Storage buffer: PBS, 0.1% rBSA, 0.05% azide

Clone: PDL2/2676

Immunogen: Recombinant fragment (around aa 27-220) of human PD-L2 protein (exact sequence is proprietary)

Antibody Reactivity: CD273/PD-L2/PDCD1LG2

Entrez Gene ID: 80380

Z-Antibody Applications: Flow (verified)/IF (verified)/WB (verified)

Verified AB Applications: Flow (verified)/IF (verified)/WB (verified)
More Information
SKU BTMBNC742676-500
Manufacturer Biotium
Manufacturer SKU BNC742676-500
Package Unit 500 uL
Quantity Unit STK
Reactivity Human
Clonality Monoclonal
Application Immunofluorescence, Western Blotting, Flow Cytometry
Isotype IgG1 kappa
Host Mouse
Conjugate Conjugated, CF740
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