PF-06447475, CAS 1527473-33-1

PF-06447475, CAS 1527473-33-1
SKU
CAY18375-10
Packaging Unit
10 mg
Manufacturer
Cayman Chemical

Availability: loading...
Price is loading...
Shelf life (days): 730

Info: An LRRK2 inhibitor (IC50 = 3 nM); inhibits LRRK2G2019S (IC50 = 11 nM); inhibits LRRK2 autoactivation in cells (IC50 = 25 nM); inhibits paraquat-induced locomotor deficiencies, decreases in survival, and increases in cranial homogenate levels of MDA in D. melanogaster; increases the number of total and tyrosine hydroxylase-expressing neurons and decreases the number of inducible nitric oxide synthase-expressing neurons in rat SNPC in a transgenic model of Lrrk2G2019S- and α-synuclein-induced model of Parkinson's disease at 30 mg/kg twice per day; reduces levels of macrophage infiltration in the ipsilateral SNPC in the same model at the same dose

Formulation: A crystalline solid

Formal Name: 3-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-benzonitrile

Purity: ≥98%

Formula Markup: C17H15N5O

Formula Weight: 305.3

CAS Number: 1527473-33-1
More Information
SKU CAY18375-10
Manufacturer Cayman Chemical
Manufacturer SKU 18375-10
Package Unit 10 mg
Quantity Unit STK
Product information (PDF)
×
MSDS (PDF)
×