Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 7-iodo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine
Purity: ≥98%
Formula Markup: C18H17IN2O3
Formula Weight: 436.2
CAS Number: 2361545-75-5
Notes: PKN3 inhibitor compound 16 is an inhibitor of serine/threonine protein kinase N3 (IC50 = 14 nM).{67885} It is selective for this kinase over a panel of 234 kinases but does inhibit serine/threonine protein kinase NLK, activin receptor type 1 (ACTR1), and receptor-interacting serine/threonine kinase 2 (RIPK2) at 1 µM, as well as cyclin G-associated kinase (GAK; IC50 = 74 nM in a bioluminescence resonance energy transfer (BRET) assay).{67885,67886} PKN3 inhibitor compound 16 inhibits viral replication in dengue virus-infected Huh7 cells (EC50 = 3.6 µM) without inducing cell death with a 50% cytotoxic concentration (CC50) value of >10 µM.{60259}
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