Description of Target: Alanyl-tRNA synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 108 kDa protein is an autoantigen recognized by PL-12 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that epitope spreading occurs in the autoimmune PL-12 response such that even antibodies to an isolated alanyl-tRNA molecule can develop. AARS Human Recombinant produced in SF9 is a glycosylated, polypeptide chain.
Molecular Weight: 108 kDa.
Product Format: Liquid 16mM HEPES buffer (pH 8), 250mM sodium chloride, 20% glycerol.
Protein Name: Alanine--tRNA ligase, cytoplasmic.
Purification: Purified by proprietary chromatographic techniques.
Purity: Greater than 90% as determined by SDS-PAGE.
Tag: 6xHis tag
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