Description of Target: Threonyl-tRNA Synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 83 kDa protein is an autoantigen recognized by PL-7 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that PL-7 antibodies (similar to Jo-1 antibodies) indicate an increased risk for lung involvement, but this needs to be confirmed for a larger number of cases. TARS Human Recombinant produced in SF9 is a glycosylated, polypeptide chain.
Molecular Weight: 83 kDa.
Product Format: Liquid 20mM HEPES buffer (pH 8), 200mM sodium chloride, 20% glycerol.
Protein Name: Threonine--tRNA ligase, cytoplasmic.
Purification: Purified by proprietary chromatographic techniques.
Purity: Greater than 90% as determined by SDS-PAGE.
Tag: 6x-His tag
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