Clone: ZR4.
Background: For the evaluation of prognosis and hormone dependency of mamma carcinoma oestrogen and progesterone receptors are determined in the affected tissues. Progesterone receptors are regulated by oestrogens. The antibody to progesterone receptor is well suited to detect the nuclear receptor proteins in appropriate processed tissue sections. For evaluation of prognosis it should always be used in parallel with the determination of oestrogen receptor, EGF receptor, cathepsin D and all relevant clinical factors. Cells and tissues, which are stimulated by the steroid hormone progesterone exhibit specific receptor proteins in their cell nuclei, binding the hormone and transducing the signal. Among these cells are epithelial cells of the uterine myometrium as well as normal and hyperblastic epithelial cells of the breast glands. Human progesterone receptor protein .
Positive Control: Lobular and tubular mamma carcinoma.
Immunogen: Recombinant fragment of human progesterone receptor aa 412-526.
Purification Method: Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**.
References: 1. Stewart J., King R., Hayward J., et al. (1982) Oestrogen and progesterone receptors: correlation of response rates, sites and timing of analysis. Breast Cancer Research and Treatment 2; 243-252. 2.. Clark G.M., McGuire W.L., Hubay C.A. et al. (1983) Progesterone receptors as a prognostic factor in stage II breast cancer. The New England J. Med. 309(22); 1343-1347. 3. Giri D.D., Goepel J.R., Rogers K., et al. (1988) Immunohistological demonstration of progesterone receptor in breast carcinomas: correlation with radioligand binding assays and oestrogen receptor immunohistology. J. Clin. Pathol. 41; 444-447. 4. Kell D.L., et al. (1993) Immunohistochemical analysis of breast carcinoma estrogen and progesterone receptors in paraffin-embedded tissue: Correlation of clones ER 1D5 and 1A6 with a cytosol-based hormone receptor assay. Appl. Immunohistochem. 1(4); 275 ff.
Caution: *These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals. ** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!
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