PROTAC HDAC6 degrader 4

Product Description: PROTAC HDAC6 degrader 4 (Compound 17c) is the PROTAC degrader for HDAC6 with a DC50 of 14 nM. PROTAC HDAC6 degrader 4 exhibits inhibitory activit against HDAC1, HDAC2, HDAC3 and HDAC6 with IC50s of 2.2, 2.37, 0.61 and 0.295 μM, respectively[1]. (Pink: ligand for target protein HDAC6 ligand-3 (HY-172360); Black: linker (HY-138387); Blue: ligand for cereblon E3 ligase (HY-W093272))

Applications: Cancer-programmed cell death

Formula: C39H42FN9O7

References: [1]Stopper D, et al. Development of Ethyl-Hydrazide-Based Selective Histone Deacetylase 6 (HDAC6) PROTACs[J]. ACS Medicinal Chemistry Letters, 2025.

Molecular Weight: 767.81

Research Area: Cancer

Target: HDAC;PROTACs

• SKU: MEXHY-172359-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-172359-0
• Package Unit: Get quote
• Quantity Unit: STK