PROTAC Mcl1 degrader-1, CAS 2163793-38-0

Product Description: PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC50 of 0.54 μM[1].

Applications: Cancer-programmed cell death

Formula: C45H45BrN6O8S

References: [1]Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.

CAS Number: 2163793-38-0

Molecular Weight: 909.84

Compound Purity: 98.13

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Bcl-2 Family;PROTACs

• SKU: MEXHY-125877-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-125877-100
• Package Unit: 100 mg
• Quantity Unit: STK