PTI-125 (hydrochloride), CAS 2480226-06-8

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 8-methyl-1-(phenylmethyl)-1,4,8-triazaspiro[4.5]decan-2-one, dihydrochloride

Purity: ≥98%

Formula Markup: C15H21N3O / 2HCl

Formula Weight: 332.3

CAS Number: 2480226-06-8

Notes: PTI-125 is a purported binding agent of filamin A, a cytoskeletal protein said to stabilize the interaction between amyloid-β (1-42) (Aβ42) and the α7 nicotinic acetylcholine receptor (nAChR).{68905,68906} PTI-125 reportedly binds to filamin A to reverse an aberrant conformational change induced by Aβ42, which prevents and reverses Aβ42-α7 nAChR binding and improves neuropathological outcomes in the 3xTg mouse model of Alzheimer’s disease. However, the data regarding PTI-125 have prompted expressions of concern by the journals in which the data were published.

• SKU: CAY41859-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41859-10
• Package Unit: 10 mg
• Quantity Unit: STK