Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4,4'-((1E,1'E)-(1-((3-(dimethylamino)propyl)sulfonyl)-4-oxopiperidine-3,5-diylidene)bis(methaneylylidene))dibenzonitrile
Purity: ≥95%
Formula Markup: C26H26N4O3S
Formula Weight: 474.6
CAS Number: 2376297-69-5
Notes: PTX80 is an antagonist of p62 (IC50 = 31.18 nM for the human receptor).{51896} It decreases the soluble fraction of p62 in MM.1S multiple myeloma cells when used at a concentration of 1.5 µM. PTX80 (200 nM) increases the levels of polyubiquitinated proteins in MM.1S cells. It induces apoptosis in MM.1S cells when used at a concentration of 100 nM. PTX80 (50-400 nM) decreases the survival of CD138+ cells, but not CD138- cells, in primary plasma cells derived from patients with multiple myeloma. It reduces the viability of tumor tissue samples isolated from ten patient-derived xenograft (PDX) mouse models of colorectal cancer (IC50s = 113-1,220 nM). In vivo, PTX80 (8 or 12 mg/kg twice per week) reduces tumor volume in an HCT116 colorectal cancer mouse xenograft model.
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