PU-H71 (hydrate), CAS 1202865-65-3

Shelf life (days): 1460

Info: An Hsp90 inhibitor (IC50 = 16.1 nM in a fluorescence polarization assay); induces HER2 degradation via disrupting Hsp90-HER2 interactions and decreases growth in SK-BR-3 breast cancer cells (IC50 = 50 nM for both); decreases viability of MM.1S and dexamethasone-resistant MM.1R cells at 1 µM; It induces cell cycle arrest at the G1/S phase in MM.1R cells at 100 nM; decreases tumor volume in MDA-MB-231 and HCC1806 breast cancer xenograft mouse models at 75 mg/kg every other day

Formulation: A crystalline solid

Formal Name: 6-amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine, hydrate

Purity: ≥98%

Formula Markup: C18H21IN6O2S • XH2O

Formula Weight: 512.4

CAS Number: 1202865-65-3

• SKU: CAY11450-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 11450-5
• Package Unit: 5 mg
• Quantity Unit: STK