Product Description: Pyrazofurin is an antitumor pyrimidine nucleoside analogue and a orotate-phosphoribosyltransferase inhibitor. Pyrazofurin inhibits cell proliferation and intracellular DNA synthesis by inhibiting uridine 5'-phosphate synthase. Pyrazofurin is also an antibiotic with a broad spectrum of antiviral activity[1][2][3][4].
Applications: Cancer-programmed cell death
Formula: C9H13N3O6
References: [1]Ringer DP, et al. Alteration in de novo pyrimidine biosynthesis during uridine reversal of pyrazofurin-inhibited DNA synthesis. Neuropsychopharmacology. J Biochem Toxicol. 1991 Spring;6(1):19-27./[2]Peters GJ, et al. Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines. Nucleosides Nucleotides Nucleic Acids. 2018;37(6):329-339./[3]Petrie CR 3rd, et al. Synthesis and biological activity of certain nucleoside and nucleotide derivatives of pyrazofurin. J Med Chem. 1986 Feb;29(2):268-78. /[4]Canonico PG, et al. Antiviral efficacy of pyrazofurin against selected RNA viruses. Antiviral Res. 1982 Dec;2(6):331-7.
CAS Number: 30868-30-5
Molecular Weight: 259.22
Compound Purity: 98.18
Research Area: Cancer; Infection
Solubility: DMSO : 50 mg/mL (ultrasonic)/H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Antibiotic;DNA/RNA Synthesis;HIV;Influenza Virus;SARS-CoV
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