Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[(1S)-2-[(3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-4-oxo-1-piperidinyl]-2-oxo-1-(phenylmethyl)ethyl]-2-chloro-acetamide
Purity: ≥98%
Formula Markup: C30H25ClN4O7
Formula Weight: 589.0
CAS Number: 2649154-57-2
Notes: RA-375 is an inhibitor of the ubiquitin-proteasome system.{68896} It inhibits the degradation of a polyubiquitinated reporter protein in a reporter assay using HEK293T cells when used at concentrations of 0.3125 or 0.625 µM. RA-375 (1 µM) increases levels of mRNA encoding DNA damage-inducible transcript 3 (DDIT3), also known as C/EBP homologous protein (CHOP), and X-box binding protein 1 (XBP1), both of which are endoplasmic reticulum (ER) stress markers, in ES-2 ovarian cancer cells. It also increases levels of reactive oxygen species (ROS) and induces apoptosis in ES-2 cells when used at a concentration of 1 µM. In vivo, RA-375 reduces tumor growth in an ES-2 mouse xenograft model.
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