Target Synonym: NEF;S100;S100-B;S100beta;S100B;S100 beta;S100 calcium-binding protein B;S-100 protein beta chain;S-100 protein subunit beta;Protein S100 B;Protein S100-B;S 100 calcium binding protein beta chain;S 100 protein beta chain;S100 calcium binding protein B;S100 calcium binding protein beta (neural);S100 protein beta chain
Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
Immunogen: A synthetic peptide corresponding to the N-terminus of the Human S100B
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:200-1:1000
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