Rheb Inhibitor NR1, CAS 2216763-38-9

Shelf life (days): 1460

Info: A Rheb inhibitor; inhibits Rheb-dependent mTORC1 activity (IC50 = 2.1 µM); selectively inhibits Rheb-depedent mTORC1 activity over Rheb-independent mTORC1 activity, mTORC2, Ras, and Rap1 at 30 µM; decreases the size of Jurkat T cells and inhibits protein synthesis in MCF-7 breast cancer cells at 10 µM; inhibits the phosphorylation of the mTORC1 substrates S6 and 4E-BP1 in mouse skeletal muscle and kidneys at 30 mg/kg

Formulation: A solid

Formal Name: 4-bromo-6-[(3,4-dichlorophenyl)thio]-1-[[4-[(dimethylamino)carbonyl]phenyl]methyl]-1H-indole-2-carboxylic acid

Purity: ≥98%

Formula Markup: C25H19BrCl2N2O3S

Formula Weight: 578.302

CAS Number: 2216763-38-9

• SKU: CAY43360-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 43360-1
• Package Unit: 1 mg
• Quantity Unit: STK